Kurt Wüthrich Distinguished Adjunct Professor
Degree 🤚：Ph.D. Affiliation ： Position ： Principal Investigator Honor ： Final education ： Graduate School ： Tel ： Fax ： Office ：Ren Bldg. C806 Add ： Email ：wuthrich@shanghaitech.edu.cn Research Group👩‍🍼： Group Website： Research Area🎅🏼：Biomolecular NMR spectroscopy in solution

Education Background

  • 1957-1962, University of Bern, Switzerland, Chemistry, physics and mathematics, Lizentiat
  • 1962-1964, University of Basel, Switzerland, Chemistry, Ph.D.
  • 1962-1964, University of Basel, Switzerland, Eidgenössisches Turn- und Sportlehrerdiplom

Working Experience

  • 1964-1965, University of Basel, Switzerland, Postdoctoral training (Prof. S. Fallab)
  • 1965-1967, University of California, Berkeley, CA, USA, Postdoctoral training (Prof. R.E. Connick)
  • 1967-1969, Bell Telephone Laboratories, Murray Hill, N.J., USA, Member Technical Staff, Biophysics Department (Dr. R.G. Shulman).
  • 1969, ETH Zurich, Zurich, Switzerland, Privatdozent (70), Assistant Professor (72), Associate Professor (76), Professor of Biophysics (80); Chairman Biology Department (95–2000)
  • 2001, Scripps Research, La Jolla, CA, USA, Cecil H. and Ida M. Green Professor of Structural Biology
  • 2013, 意昂 Institute, ShanghaiTech University, Shanghai, China, Distinguished Senior Professor

Research Interests

For 50 years, Wüthrich groups at the ETH Zürich, Zürich, Switzerland, Scripps Research, La Jolla, CA, USA and the 意昂 -〈注册即享〉超值礼包等你领取！ University, Shanghai, China have worked on nuclear magnetic resonance spectroscopy (NMR) with biological macromolecules. Contributions include the method for macromolecular structure determination with NMR in solution and the use of the principles of transverse relaxation-optimized spectroscopy (TROSY) for NMR experiments with large supramolecular assemblies. Applications over the years were focused on differentiation in higher organisms, immune suppression and neuropathology. As of June 1, 2026, research using NMR techniques is continued at ShanghaiTech University, with a focus on G protein-coupled receptors (GPCRs). 


CV of Prof. Wüthrich: Wüthrich Kurt CV (E) 260330.pdf

Research Achievement

Representative Publications

Ge, H., Yang, L., Chen, C., Xu, Y., Liu, D. and Wüthrich, K. (2025) J. Am. Chem. Soc. 147, 44114–44122. Human Substance P Interactions with G Protein-Coupled Receptor NK1R Observed by NMR in Solution.

Guo, C., Yang, L., Liu, J., Liu, D. and Wüthrich, K. (2025) Cell Chem. Biol. 32, 1140–1149. Structural basis of adenosine 2A receptor-balanced signaling activation relies on allosterically mediated structural dynamics.

Pan, B., Liu, D., Yang, L. and Wüthrich, K. (2022) Proc. Natl. Acad. Sci. USA 119, doi: 10.1073/pnas.2122682119. GPCR large-amplitude dynamics by 19F-NMR of aprepitant bound to the neurokinin 1 receptor.

Shimada, I., Ueda, T., Kofuku, Y., Eddy, M.T. and Wüthrich, K. (2019) Nat. Rev. Drug Disc. 18, 59–82. GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures.

Eddy, M.T., Lee, M.-Y., Gao, Z.-G., White, K.L., Didenko, T., Horst, R., Audet, M., Stanczak, P., McClary, K.M., Han, G.W., Jacobson, K.A., Stevens, R. and Wüthrich, K. (2018) Cell 172, 68–80. Allosteric coupling of drug binding and intracellular signaling in the A2A adenosine receptor.

Liu, J.J., Horst, R., Katritch, V., Stevens, R.C. and Wüthrich, K. (2012) Science 335, 1106–1110. Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.

Wüthrich, K. (2003) Angew.Chem. Int. Ed. 42, 3340−3363. NMR studies of structure and function of biological macromolecules (Nobel Lecture).

Fiaux, J., Bertelsen, E., Horwich, A. and Wüthrich, K. (2002) Nature 418, 207–211. NMR analysis of a 900K GroEL–GroES complex.

Pervushin, K., Riek, R., Wider, G. and Wüthrich, K. (1997) Proc. Natl. Acad. Sci. USA 94, 12366–12371. Attenuated T2 relaxation by mutual cancellation of dipole–dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution.

Wüthrich, K. (1986) NMR of Proteins and Nucleic Acids, Wiley, New York.

Wüthrich, K. (1969) Proc. Natl. Acad. Sci. USA 63, 1071–1078. High resolution proton nuclear magnetic resonance spectroscopy of cytochrome c.


Complete publication list of Prof. Wüthrich: PUBLICATIONS MASTER 2026 03 04.pdf


Monograph

Patent

Funding

Awards

Group Member

  • Name：Dongsheng Liu
    Position🧚🏽：Research Associate Prof.
    Duration✍🏽🍼：2014 –
    Email：liudsh@+@shanghaitech.edu.cn
  • Name：Canyong Guo
    Position：Research Assistant Prof.
    Duration：2025 –
    Email：guocy2@+@shanghaitech.edu.cn
  • Name：Xiaoqian Bai
    Position：Engineer
    Duration👺：2023 –
    Email：baixq@+@shanghaitech.edu.cn
  • Name⚖️：Chen Chen
    Position🧛🏼：Ph.D student
    Duration👷🏼：2020 –
    Email：
  • Name：Chuanfeng Zheng
    Position：Ph.D student
    Duration：2020 –
    Email🍻：
  • Name👶🏼：Changran Chen
    Position👩🏼‍🌾🍡：Ph.D student
    Duration🍰：2021 –
    Email🫱🏽：
  • Name：Qiangqiang Zhang
    Position🤾‍♀️：Ph.D student
    Duration：2021 –
    Email：
  • Name🤰🏿：Ziyao Yang
    Position：Ph.D student
    Duration：2022 –
    Email🤹🏽‍♀️：
  • Name：Jingqian Hu
    Position：Ph.D student
    Duration：2023 –
    Email：
  • Name👣：Baike Ning
    Position：Ph.D student
    Duration：2023 –
    Email👷‍♀️：
  • Name：Chenjun Li
    Position：Master student
    Duration：2025 –
    Email：
  • Name🔼：Lekang Sun
    Position🎅🔮：Master student
    Duration🪞：2025 –
    Email🩸：
  • Name：Yaguang Hou
    Position：Study Manager, Roche China Holding Ltd.
    Duration：2014 – 2017
    Email：
  • Name：Tiandan Xu
    Position💃🏽：WuXi Biologics. Co., Ltd.
    Duration：2014 – 2019
    Email：
  • Name：Wanhui Hu
    Position🧑🏻‍🦯：Asscociate Director, Shanghai Jeyou Pharmaceutical Co.,Ltd.
    Duration：2015 – 2019
    Email：
  • Name：Huixia Wang
    Position：Postdoctoral Fellow, University of California, San Francisco
    Duration👨🏼‍🚒：2015 – 2021
    Email👮🏽‍♂️：
  • Name：Benxun Pan
    Position：Research Assistant Professor, Lingang National Laboratory
    Duration：2016 – 2022
    Email：
  • Name：Jinfeng Zhang
    Position👨‍🍳：Research Project Manager, ShanghaiTech University
    Duration：2017 – 2022
    Email👩‍🦼‍➡️：
  • Name：Dandan Feng
    Position：Research Assistant Professor, Westlake University
    Duration：2017 – 2023
    Email：
  • Name：Guanru Feng
    Position🙍‍♀️：Researcher, Shanghai Henlius Biotech
    Duration：2018 – 2020
    Email👄：
  • Name⚠️：Canyong Guo
    Position：Research Assistant Professor, ShanghaiTech University
    Duration🗺🧔🏼‍♀️：2018 – 2025
    Email💅：
  • Name🛣：Yanzhuo Song
    Position⚛️：Director Enzyme Engineering, MGI Tech Co., Ltd.
    Duration🦧：2018 – 2020
    Email：
  • Name👇🏿：Francisco Mendoza‑Hoffmann
    Position：Professor, Autonomous University of Baja California
    Duration：2019 – 2021
    Email💪🏽：
  • Name：Yanliu Fan
    Position🪬：Researcher I, Shanghai Ailux Biotechnology Co., Ltd.
    Duration👰🏿：2019 – 2022
    Email：
  • Name🧼：Haoyi Ge
    Position：Senior scientist I, AstraZeneca
    Duration：2019 – 2025
    Email：
  • Name🦹🏼‍♀️：Yuxin Xu
    Position🫃🏽：Bloomage Biotech
    Duration：2020 – 2023
    Email：
  • Name：Ziyi Wang
    Position：Ph.D candidate, Shanghai Jiaotong University
    Duration：2021 – 2024
    Email：
  • Name🚆：Qi Ouyang
    Position👩‍⚖️：Ph.D candidate, Shanghai Jiaotong University
    Duration👰🏿‍♀️：2021 – 2024
    Email：

Group Photo

Work

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